Effect of dietary administration of Chinese torreya nut on reproductive function in <i>ICR female mice</i> and its possible mechanism of action

Chinese torreya nut (Torreya grandis cv. Merrillii) is a unique edible that grows in China, which known for its ability to reduce blood lipids, prevent sclerosis, and coronary heart disease. However, effect on reproduction not well understood. In this study, the comprehensive effects of sex hormones endometrium female mice their uterine expression profiles were investigated. Here, feeding with resulted decrease coefficients serum progesterone levels, thickening endometrium, an increase estrogen levels. The enrichment analyses indicated differentially expressed genes between addition control enriched NOD-like receptor signaling pathway, complement coagulation cascades p53 pathway. Quantitative real time PCR western blot results showed there significant differences transcripts protein alpha progestogen associated G coupled receptor. These findings suggest may have potentially beneficial coordinating contractions mice, rendering it promising functional food.